• SIP
• S
• A phenol derivative with two isopropyl groups attached at positions 2 & 6, hence it's name - 2,6 diisopropylphenol
• Molecular weight 178
• I
• Indicated for the induction and/or maintenance of anaesthesia, sedation in an ITU/theatre environment and in small doses can be used as an anti-emetic (rarely)
• P
• Presented in isotonic lipid emulsion with 10% soybean oil, 2.25% glycerol and 1.2% egg phosphatide, NaOH and water
• pH 6-8.5, pKa 11 => at physiological pH is almost entirely unionised
• TROADES
• T
• For induction of anaesthesia or infusion
• R
• Route of administration - IV
• O
• Onset in 1 arm-brain circulation time
• A
• Mechanism of action is unclear but may reduce opening times of Na⁺ channels in the CNS and have regulatory effect on inhibitory glycine receptors and GABA receptors
• D
• 2-2.5 mg/kg induction dose (less in physiologically unstable/elderly)
  4-12mg/kg/hr for sedation
  0.3-0.4 mg/kg for sedative dose
• E
• Induces anaesthesia in 1 arm-brain circulation time
• S
• CNS
• ↓CPP/CMRO/ICP
• Steady CBF
• CVS
• ↓SVR/c.o./BP
• ↑/↓HR
• Resp
• ↓VT/RR/laryngeal reflexes
• Others
• Crosses placenta
• Safe in porphyria
• Can cause propofol infusion syndrome
• MEAD
• M
• Metabolised mainly in the liver to glucoronide/sulphate metabolites but also by kidneys
• Unaffected clinically by renal/hepatic disease
• E
• Eliminated in the urine
• Clearance 30-60ml/kg/min
• A
• Bioavailability 100% (IV route only used)
• 95% protein bound
• D
• Vd 4L/kg
• Redistribution T½ 1.5-4 mins
• Elimination T½ 5-12 hrs
• Propofol is a common drug so in-depth knowledge will be expected! Try using the structure explained in the linked mindmap
  Link:Drug descriptions