• Chronic pain drugs
• Anti-epileptic drugs
• Work in a variety of ways
• Phenytoin and carbamazepine reduce axonal activity by blockage of sodium channels
• Gum hypertrophy, diplopia, cerebellum signs
• Lamotrigine causes reduced release of glutamate
• Dizziness, rash
• Valproate elevates levels of GABA in the CNS
• Hepatotoxicity, oedema, weight gain, hair loss
• Gabapentin has inhibitory action at voltage gated calcium channels blocking the α2δ subunit.
• Dizziness, fatigue, poor concentration, headache, weight gain, neutropenia
• Pregabalin works similar to gabapentin
• As for gabapentin
• Antidepressants
• Thought to be related to central blockade of CNS mono amine uptake (serotonin +/or NA). May enhance descending inhibitory pathways. They also have effect on H1, NMDA, α-adrenergic receptors and μ receptors
• S/E are sedation, anticholinergic effects and may slow AV and intraventricular conduction. NNT is about 2.5
• CEACCP
  Link:ceaccp.oxfordjournals.org/content/5/4/134.full.pdf