• Guillain-Barré syndrome
    • Acute demyelinating poly neuropathy
    • Features
      • Motor weakness
      • Areflexia
      • Facial palsy
      • Sensory symptoms
      • Opthalmoplegia
      • Back pain
      • Respiratory failure
      • Autonomic dysfunction
      • Arrhythmias, ileus
    • Intubation guidance
      • VC < 20 ml/kg
      • PIP < 30cmH₂O
      • PEP < 40cmH₂O
      • Decrease of 30% from baseline
    • Tests
      • FBC
      • U&E
        • SIADH seen
      • LFT
        • Often abnormal
      • CS
        • If plasmapheresis considered
      • Anti-ganglioside ABs
        • Anti-GMI
        • GQI
      • Stool culture
        • Capmpylobacter
      • CT & LP
        • High protein
      • Gad MRI
        • Nerve root enhancement
      • TFT, B12, Hep ABC serology, HIV
    • Poor prognosis
      • Old age
      • Campylobacter
      • Anti-GMI Ab
      • NSE/S100 in CSF
      • Requiring ventilation
      • Upper limb paralysis
    • Treatments
      • Supportive
        • Physio/OT
        • Counselling
        • Nutrition
        • Analgesia
        • TED prophylaxis
        • Respiratory support
          • VC <20ml/kg
          • Max insp pressure <30cm H₂O
          • Decrease in VC of > 30%
        • IV Ig
        • Plasma exchange
        • CSF filtration
    • Causes
      • Post viral
        • CMV, mycoplasma, EBV related
      • SLE
      • Lymphoma
      • HIV
      • COCP
      • Pregnancy
    • CEACCP
      Link:ceaccp.oxfordjournals.org/content/3/2/46.full.pdf