• Classifications 2
    • Measurement of CBF
      • Fick principle (Katy-schmit)
      • Radioactive 133Xe
      • Positron emission
      • TCD
      • Indwelling oximetric catheters
      • Jugular bulb catheterisation
    • Antihypertensives
      • Centrally acting
        • E.g. Clonidine, reserpine, methyldopa
      • Acting on the heart and vasculature
        • β-blockers
          • Non-selective (eg timolol, sotolol)
          • Selective (eg bisoprolol, atenolol, metoprolol)
        • α-blockers
        • ACE(i)
        • ATIIRA
        • Calcium channel blockers
        • Nitrates/SNP
        • K+ channel activators
        • Hydralazine
      • Acting on the kidney
        • Diuretics
        • Direct renin inhibitors
    • Cardiac output measurement
      • Invasive
        • PA catheter
        • Thermodilution
        • PICCO
        • Dye dilution
      • Semi-invasive
        • ODM
      • Non-invasive
        • Transthoracic doppler
        • MRI
        • Thoracic impedance
        • Ballisticocardiography
    • NMJ blockers
      • Drugs preventing ACh synthesis
        • Hemicholinium
      • Drugs preventing ACh release
        • Aminoglycosides, botulinum
      • Drugs depleting ACh stores
        • Tetanus toxin
      • Drugs blocking ACh receptors
        • NMBDs
    • NMJ monitoring devices
      • Mechanical force transducers
      • Accelerometers
      • EMG
    • Drug interactions
      • Physical/pharmaceutical
        • Outside the body
          • E.g. Thio & sux
        • Inside the body
          • Penicillamine in Wilson's disease
      • Pharmacodynamic
        • Direct
          • Flumazinil & BDZ, opiates & naloxone
        • Indirect
          • Neostigmine & reversal of NMBDs
      • Pharmacokinetic
        • Absorption
          • Charcoal, metoclopramide, muscarinic antagonists
        • Distribution
          • Reduced c.o. By beta blockers reduces speed of absorbed drug reaching site, or drugs displacing others protein binding
        • Metabolism
          • Enzyme inducers
        • Elimination
          • Alter urinary pH
    • Drug actions
      • Physicochemical
        • E.g. Antacids, mannitol, charcoal, chelating agents
      • Enzyme inhibitors
        • E.g. NSAIDS, ACE(i)
      • Receptors
        • Altered ion permeability
          • Ionotropic glutamate (NMDA)
          • Ionotropic purinergic (PX1/2)
          • Pentameric (ACh)
        • Intermediate messangers
          • GPCR (beta agonists, opiates)
          • Tyrosine kinase (insulin, GF)
          • Guanyl cyclase (eg NO/ANP)
        • Regulation of gene transcription (eg cytoplasmic receptors)
    • Vaughan-Williams Classification
      • Class 1
        • Ia
          • Disopyramide, quinidine, procainamide
            • Double Quarter Pounder, Lettuce & Pickles, Fries
        • Ib
          • Lidocaine, phenytoin
        • Ic
          • Flecainide
      • Class 2
        • β-blockers
      • Class 3
        • K⁺ channel blockers
          • Amiodarone, sotolol
      • Class 4
        • Calcium antagonists