• Anticoagulants
• Inhibit platelet function
• NSAIDS
• Inhibit COX enzymes so reduce thromboxane A2 production, inhibiting platelet aggregation
• Clopidogrel
• Irreversibly blocks the ADP receptor so inhibits activation of the glycoprotein IIb/IIIa receptor
• Dipyridamole
• Inhibits platelet phosphodiesterase which normally breaks down cAMP. High cAMP levels inhibit platelet aggregation
• Abciximab
• Synthetic antibody which binds to glycoprotein IIb/IIIa receptor, so prevents binding by fibrinogen
• Dextrans
• Large chain carbohydrates with inhibitory effect on Von Willebrand's factor so causes anticoagulant effect
• Prostacyclin
• Produced endovascularly leading to local vasodilatation and inhibition of plt aggregation
• Breakdown clot once formed
• Streptokinase
• Alteplase
• Alter clotting cascade
• Vitamin K antagonists
• Warfarin/phenindione
• Factor Xa inhibitors
• UFH
• LMWH e.g. Enoxaparin
• Oligosaccharides e.g. Fondaparinux
• Heparinoids e.g. Danaparoid sodium
• Direct thrombin inhibitors
• Univalent compounds e.g. Argatroban
• Bivalent compounds e.g. Lepirudin
• Others
• Activated protein C